2 Popular Canadian Drugs To Fight Diabetes

According to the National Diabetes Statistics, 2011, provided by the National Diabetes Information Clearinghouse (NDIC), nearly 10.9 million or 26.9% of Americans ageing 65 years or above are suffering from diabetes. Furthermore, 215, 000 or 0.26% of individuals below the age of 20 years are suffering from type1 or type2 diabetes. Nearly 1.9 million people ageing 20 years or more were newly diagnosed with the disease in 2010. Diabetes is a leading cause of kidney diseases, limb amputations, blindness, nervous system diseases, high blood pressure, cardiovascular diseases and stroke. Avandamet and Janumet are two highly effective anti-diabetic Canadian drugs that can help in the treatment of the disease.

Canadian Drugs: Avandamet and Janumet
Prior to purchasing these anti-diabetic Canadian drugs it is important to know about their uses, mechanism and side effects:
Canadian Drugs: Avandamet Mechanism
One of the most popular Canadian drugs, Avandamet is administered along with proper diet and exercise to treat type2 diabetes. It contains two oral anti-diabetic drugs called metformin hydrochloride and rosiglitazone maleate. Avandamet works by improving insulin sensitivity and glycemic control in the diabetic patients.
In type2 diabetes pancreas of the body is unable to produce enough insulin to regulate the blood glucose levels. Additionally, the body is unable to use the available insulin effectively. The two active substances present in Avandamet take different modes of action:
Rosiglitazone Maleate: It is a member of the class of drugs known as thiazolidinediones. It makes the body cells (liver, fat and muscle) more sensitive towards insulin. This helps the body to make a better use of the available insulin.
Metformin Hydrochloride: It is a member of the class of medicines known as biguanide. It works by inhibiting production of the glucose and reducing the intestinal absorption of glucose.
Side Effects of Avandamet
Some common side effects of Avandamet are:
Headache
Diarrhea
Nausea
Vomiting and stomach upset
Tired feeling
Back and joint pain
Canadian Drugs: Janumet Mechanism
Janumet is a FDA-approved oral diabetes drug used to treat type2 diabetes. The drug is a combination of two drugs sitagliptin and metaformin, which are used to reduce blood glucose levels in type2 diabetics. Metaformin present in Janumet works in a similar manner as it works in Avandamet.
However, Sitagliptin has a different mode of action. It regulates the levels of insulin and lowers the blood glucose levels in the type2 diabetics. Incretin hormones, such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are released by the intestines, following a meal. These hormones play an important role in increasing the production of insulin from pancreas and reducing the blood glucose levels. Sitagliptin inhibits the action of the enzyme DPP-4, which destroys GIP and GLP-1. This increases the levels of GIP and GLP-1 in the body resulting in increased production of insulin and reduced blood glucose levels.
Side Effects of Janumet
Some of the common side effects of Janumet are:
Abdominal pain
Diarrhea
Nausea and vomiting
Hypoglycemia
Weakness
Stuffy and runny nose

By: Jeff Warner

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