Since the follicular walls in the pilo-sebaceous unit is intact before adolescence, it has been postulated that if colonization of Proprionibacterium acnes occurs in sufficient numbers they produce antigenic molecules that promote the initiation of inflammation. Proprionibacterium acnes can synthesize proteinases, lipase, and hyaluronate lyase all of which can serve as the catalysts or initiators of the inflammatory infiltrate which is composed of neutrophils and lymphocytes.
Hormonal Cause of acne
The crucial player in the cause of acne in puberty is hormones. At this stage androgens interact with receptors on the sebaceous glands and promote stimulation of the sebaceous gland to hypertrophy and hence induce more sebaceous production of lipids and free fatty acids which distend the follicular conduct. More specifically, there is evidence for enhanced peripheral metabolic conversion of the androgen testosterone to dihydrotestosterone at the level of the skin in people suffering from acne.
How Acne Forms
The first lesion in this condition called acne vulgaris is the comedo. When in contact with oxygen the comedo turns dark and creates what you know as a blackhead. The comedo is created by retention of layers of devitalized skin known as keratin in the walls of the follicles. In addition to hyperkeratosis (which is thickening or trapped layers of keratin), there is an accumulation of sebum. The mixture of the keratin and the sebum leads to a plugging of the opening of the follicular conduct, and papules are made by inflammation around the comedones. Depending upon the degree of inflammation, granulomatous reactions, cysts, cars, pustules, nodules, and keloids can develop.
Development of Acne
Inflammatory Response
Airborne contamination and other toxic materials further aggravate the inflammatory reaction. As bacteria start to proliferate inside the blocked pore your defensive system responds by releasing granulocytes and macrophages, which are types of white blood cells that destroy the bacteria. The inflammation process is necessary to eliminate the continuing consequences of excess bacteria and signal the body to repair the harm to tissues. Often times the defensive response system can't stop the multiplication of acne bacteria due to lack of leukocytes or an impaired system.
Activity of the Sebaceous Gland
When a comedo is blocking the exit of the sebum ducts, the sebaceous glands continue to produce sebum, which accumulates in the sebum conduct increasing the comedo in size. The expansion in size results in pressure and leads to a further intense inflammation response in the surrounding skin and produces redness, swelling, discomfort, and a mass (pimple, redhead, acne papule).
Growth of Acne Bacteria
The above conditions encourage the growth of bacteria and result in infection inside the canal, the sebaceous gland, and surrounding tissue. The commencement of the infection makes further inflammatory changes, therefore beginning a cycle of accentuated obstruction of the outflow of sebum which leads to even more pressure, inflammation, and progressing infection making cysts and pustules to occur. The consequence on skin tissues caused by such infections is very harmful and the healing process commonly results in a scar. treatments for acne
In order to find a good pimple solution, you must remember that all individuals have different needs. Try various acne products, beginning with the milder one, until you find what works for you. A good skin treatment can be the end of your acne.
Scars, imperfections and marks left behind by various acne conditions can now be quickly faded thanks to a natural skin care product made with a non-allergenic, non-irritant special component for the regeneration of your skin.
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