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Reglan Tardive Dyskinesia
The Reglan drug, also known by the generic name “metoclopramide”, was first approved by the FDA in 1980. It is currently available in several different forms in both the branded “Reglan” and generic “metoclopramide” products. Reglan medication is commonly misspelled as: Reglun, Regland and Reglund. Reglan is prescribed for both adults and children depending on the treatment. The drug is used for several different therapies including: • Acid reflux • GERD (gastroesphageal reflux disease) • Diabetic gatroparesis • Nausea from migraines and following surgery • Breastfeeding mothers – increase milk production Gastroesophageal reflux is a common disorder that occurs when the lower esophageal sphincter either opens spontaneously or does not close properly and stomach contents, including acid, rise up into the esophagus. Reglan increases stomach and small intestine contractions which speeds up the rate at which the stomach empties into the intestines. The Reglan drug has recently come under scrutiny due to the risk of developing the neurological side effect Tardive Dyskinesia. The FDA announced that manufacturers of metoclopramide must add a boxed warning to their drug labels about the risk of developing tardive dyskinesia after prolonged use. The FDA’s Center for Drug Evaluation and Research director stated “The chronic use of metoclopramide therapy should be avoided in all but rare cases where the benefit is believed to outweigh the risk.” Recommended gastroesophageal reflux doses: The usual dose of Reglan is 10 milligrams to 15 milligrams, up to 4 times a day, 30 minutes before each meal and at bedtime, depending upon the symptoms being treated and the effectiveness of the dose. Treatment should last no longer than 12 weeks. Recommended diabetic gastroparesis doses: The usual dose of Reglan is 10 milligrams 30 minutes before each meal and at bedtime for 2 to 8 weeks. Reglan medication is also manufactured as the generic “metoclopramide” form several different pharmaceutical companies including: • Wyeth • Actavis • ANI Pharmaceuticals • Baxter • Hospira/Mayne Pharmaceuticals • Morton Grove Pharmaceuticals • URL Pharma • Qualitest Pharmaceuticals • Schwarz Pharma • Teva Pharmaceutical Tardive dyskinesia (TD) is a drug-induced movement disorder caused by the long-term use of neuroleptic drugs. Tardive means “delayed” and dyskinesia means “abnormal movement.” This serious neurological syndrome is often irreversible and may become permanent. Since the 1950’s a family of drugs referred to as dopamine receptor blocking drugs (DRB) have been prescribed for certain mental health conditions and are now also commonly prescribed for the treatment of GERD and nausea. Metoclopramide / Reglan is a dopamine receptor blocking drug. Article Directory: http://www.articledashboard.com John Humphrey is author of this article on Reglan lawsuit. Find more information about Reglan side effects here. |
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